ANTI-INFLAMMATORY ACTIVITY OF OCIMUM SANCTUM (LINN) IN FORMALIN INDUCED ACUTE MODELS OF ALBINO RATS

  • MRUTYUNJAY M MIRJE
  • SHIVAPRASAD KUMBAR
  • GURUDATTA MOHARIR

Abstract

The inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, physical injuries). Many nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone, indomethacin, etc. are in clinical use but all these are not completely devoid of adverse effects2. In this study, the anti-inflammatory activity of O. sanctum alone and in combination with indomethacin was studied using formalin-induced rat paw edema. Aqueous extract of O. sanctum (200mg/kg, 300mg/kg or 400mg/kg) was administered alone and in combination with indomethacin (25mg/kg) to separate groups of rats and paw volume was measured by plethysmometer and compared with the control group. All the test groups showed a significant (P<0.05) anti-inflammatory effect in formalin-induced rat paw edema. The reduction of edema by O. sanctum was better than that of the standard anti-inflammatory drug, indomethacin and on co-administration marginally improved the anti-inflammatory profile of indomethacin. O.sanctum possesses significant anti-inflammatory activity probably due to inhibition of both cyclooxygenase and lipooxygenase pathways of arachidonic acid metabolism (dual inhibitory property).

KEYWORDS: Nonsteroidal anti-inflammatory drugs (NSAIDs); Indomethacin; Plethysmometer.

Published
2019-06-21
How to Cite
M MIRJE, M., KUMBAR, S., & MOHARIR, G. (2019). ANTI-INFLAMMATORY ACTIVITY OF OCIMUM SANCTUM (LINN) IN FORMALIN INDUCED ACUTE MODELS OF ALBINO RATS. International Journal of Clinical and Biomedical Research, 1(1), 1-4. Retrieved from https://www.ijcbr.com/index.php/ijcbr/article/view/1
Section
Original Research Articles