The Aim of the present study is to analyze prescription pattern of the antihyperglycemic drugs in patients with type 2 diabetes mellitus (T2DM). The study included 620 T2DM out patients aged between 31 to 60 years. Sociodemographic data included mean age, educational status, marital status, duration of diabetes mellitus and BMI. Women (54.8%) shared higher percentage in study population. Metformin (44.1%) was prescribed significantly in higher cases than other antihyperglycemic drugs. Glimepiride (30%) is second most common drug prescribed in monotherapy followed by glibenclamide (9.3%), gliclazide (6.6%) in treatment of T2DM. The prescription pattern study of antihyperglycemic drugs in T2DM can serve as a guide to clinicians to select the monotherapy drug, combination drugs and insulin preparations. The findings of current study also help to the pharmaceutical companies to understand the percentage of utilization of antidiabetic drugs before developing and marketing any new drug.