ASSESSMENT OF SERUM PARAOXONASE-1 ENZYME ACTIVITY, MALONDIALDEHYDE AND VITAMIN-C IN ORAL PREMALIGNANCIES
Background: Â Oral Â premalignancies Â are Â a Â group Â of Â disease Â or Â syndromes Â which Â if Â left untreated can lead to cancer. It carries a great significance in Indian perspective. The actual figure Â of Â oral Â cancers Â arising Â from Â oral Â premalignancies Â is Â not Â known Â and Â to Â predict accurately the malignant transformations of them is still not possible. Oxidative stress is a known player behind cancerogenesis. Â Recently decreased Paraoxonase-1 activity and increased oxidative stress markers ware found to be associated with Oral Squamous Cell Carcinoma. So, there is a strong possibility of a similar finding in Oral Premalignancies too. Aim: Â This study aims to investigate the correlation between serum PON-1 activity and oxidative stress markers (MDA & Vitamin C) in patients with Oral Premalignancies. Material and Methods: A total of 62 patients with clinically diagnosed oral premalignant lesions and diseased controls were chosen for the study. Â Venous blood samples were collected and PON-1, MDA (in serum) & Vitamin c (in plasma) were analysed spectro-photometrically. Results:Â Â AÂ Â significantÂ Â decreasedÂ Â serumÂ Â PON-1Â Â activityÂ Â (P<0.05)Â Â andÂ Â concomitant significantly increased serum MDA (P <0.05) and decreased Vitamin C levels (P<0.05) were observed in premalignancies compared to the controls. These finding were more pronounced in Oral Leukoplakia (OL) than in Oral Submucous Fibrosis (OSMF) with a significant difference. Mean levels of the analysed parameters differed accordingly in the clinical grades of oral premalignancies. Conclusion: It can be envisaged that serum PON-1 activity and increased oxidative stress might be a contributing factor behind pathogenesis and progression of Oral Premalignant Diseases.
Copyright (c) 2018 Kar Param, Mohod Kanchan, Puttewar Manish, Kumar Satish
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